What Inhibits Hair Follicle Formation Driven by Hedgehog Pathway Activation?
The Hedgehog (HH) pathway is an important regulator of the formation of hair follicles.1 This pathway is activated by HH, which then binds to its receptor PTCH1, allowing for the activation of the protein SMO. SMO then inhibits the action of SUFU, allowing GLI to be activated.2 Loss of both copies of SUFU is one of the components that would inhibit hair follicle formation. This can be caused by mutations in the SUFU gene, leading to HH pathway activation.3 Loss of both copies of SMO, as well as loss of one copy of PTCH1, would also inhibit hair follicle formation.4 Finally, the constitutive activity of SMO is another pathway component that would inhibit hair follicle formation. In conclusion, hair follicle formation is driven by Hedgehog pathway activation and several components can inhibit it, such as loss of both copies of SUFU, both copies of SMO, one copy of PTCH1, and constitutive activity of SMO. Cont…
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