The Role of RNA Polymerase in Finding Genes in the Human Genome
RNA polymerase is an enzyme responsible for the transcription of DNA into RNA. A majority of the human genome consists of non-coding DNA, which does not code for proteins. Despite this, RNA polymerase is still able to locate and transcribe genes in the genome. This is achieved through a process known as promoter recognition. Promoter recognition involves the binding of RNA polymerase to specific promoter sequences, usually located upstream of the gene. Once the RNA polymerase has bound to the promoter, it will begin to transcribe the gene into an RNA molecule. Promoter sequences are typically conserved within the genome, and they allow the RNA polymerase to differentiate between genes and non-coding DNA. For example, a study published in 2019 found that promoter sequences in the human genome had a higher level of conservation than non-coding DNA, indicating that promoter recognition is indeed a key factor in locating genes (Zhang et al., 2019). Cont…
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