The Role of Rho and Xrn2 in Terminating Transcription
Rho and Xrn2 are two proteins that play important roles in the termination of transcription in bacteria and eukaryotes, respectively. In bacteria, Rho is a molecular motor that binds to the RNA polymerase (RNAP) and moves along the mRNA strand in the 3’ to 5’ direction. As it moves, it hydrolyzes the RNA transcript and disrupts the RNAP-DNA complex at the transcription termination site, thereby ending transcription (Tramonti et al., 2017). In eukaryotes, Xrn2 is an exonuclease that is part of the exosome complex. It recognizes specific signals in the transcript and cleaves the RNA at the 3’ end. This cleavage releases the transcript from the RNAP and prevents further elongation of the mRNA (Chung et al., 2020). The similarities between Rho and Xrn2 are evident. Both proteins interact with the RNAP and move along the mRNA strand in the 3’ to 5’ direction, cleaving the transcript and disrupting the. Cont…
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