The Protonation of Basic Drugs at pH 7.06. A basic drug has a pk, (for its conjugate acid) of 8.66. Calculate what percentage will be protonated at pH 7.06. Give your answer to 2 decimal places. Give the numerical answer only; you do not need to include “%” in your answe

The Protonation of Basic Drugs at pH 7.06

Drugs can exist in either a protonated or a deprotonated form, depending on the pH of the environment. The pK of a drug, which is the measure of the acidity or basicity of a compound, is an important factor in determining the percentage of the drug that will be protonated at a given pH. In the case of a basic drug with a pK of 8.66, the percentage protonated at a pH of 7.06 can be calculated. The Henderson-Hasselbalch equation can be used to solve for the percentage of a drug that is protonated at a given pH (Fine, 2017). This equation is expressed as: pH = pK + log ([Drug Protonated]/[Drug Deprotonated]). To calculate the percentage of the drug protonated at pH 7.06, the equation can be rearranged to solve for the [Drug Protonated]/[Drug Deprotonated] ratio. This ratio can then be converted to a percentage. Using the Henderson-Hasselbalch equation, the … Cont…

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