The Proportion of Uncharged Basic Drugs at pH 7.4
The proportion of a basic drug that is uncharged at a given pH can be estimated using the pKa of its conjugate acid. The pKa is the pH at which the drug is 50% protonated and 50% uncharged. For a basic drug with a pKa of 10, approximately 12.6% of the drug will be uncharged at pH 7.4 (Brouwer and Vermeulen, 2019). This is because pH 7.4 is lower than the pKa, meaning the drug is more likely to be in its uncharged form than its protonated form. The pH of a solution is an important factor to consider when trying to estimate the proportion of a drug that is uncharged. As pH increases, the proportion of uncharged drug also increases. This is because basic drugs are more likely to stay in their uncharged form at higher pHs (Chaudhuri et al. 2016). For example, at pH 10, approximately 80% of the drug would be uncharged. Therefore, it is important to consider the pH of a solution when trying to estimate the proportion of a basic drug that is uncharged. Cont…
Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.
You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.Read more
Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.Read more
Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.Read more
Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.Read more
By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.Read more