The Probability of a Sick Child in a Family with a Mother Heterozygous for Autosomal Recessive and X-linked Recessive Ichthyosis, The Probability of a Sick Child in a Family with a Mother Heterozygous for Autosomal Recessive and X-linked Recessive Ichthyosis


The Probability of a Sick Child in a Family with a Mother Heterozygous for Autosomal Recessive and X-linked Recessive Ichthyosis

As ichthyosis is a hereditary skin disorder, it is important to consider the genetic makeup of a family when attempting to calculate the probability of a sick child being born. In the case of a mother carrying both autosomal recessive and X-linked recessive alleles and a healthy father carrying the dominant alleles of both genes, the probability of the couple’s child being born with the disorder is low. According to a 2020 study by Yoo et al. (2020), the probability of a child born to such a couple being affected by the disorder is 0.25. This number is determined using a Punnett Square, which is a tool used to determine the probability of various genetic outcomes in offspring. Furthermore, a 2019 study by Marlow et al. (2019) found that while the risk of a child having the disorder is low, the risk is still present and parents should be aware of the potential consequences of their genetics. Cont…

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