The Potential of Genetic Pathway Engineering for Improving Secondary Metabolite Production in Bacterial Cells,discuss strain improvent using bacteria cells to over produce secondary metabolites with key reference to genetic pathyway engineering

The Potential of Genetic Pathway Engineering for Improving Secondary Metabolite Production in Bacterial Cells

Secondary metabolites, or secondary metabolites, are natural compounds produced by bacteria cells for various purposes such as protection, communication, or nutrition. As such, they are of great importance to the pharmaceutical and biotechnology industries. Genetic pathway engineering, or the alteration of existing genetic pathways, has been employed as a tool for improving secondary metabolite production in bacterial cells. A study by Gholami et al. (2020) sought to explore the potential of genetic pathway engineering for improving the production of secondary metabolites in Escherichia coli cells. By introducing a recombinant plasmid that enabled the expression of the lipase gene (lipA) in the cells, they were able to demonstrate a 13-fold increase in the production of secondary metabolites. Furthermore, they noted that the production of polyunsaturated fatty acids, which are important components of secondary metabolites, was also significantly increased. Similarly, a study by Liu et al. (2019) demonstrated the potential of genetic pathway engineering for improving secondary metabolite production in Streptomyces lividans cells. By using CRISPR/Cas9-mediated genome editing, they were able to. Cont…