The Odds of Unaffected Offspring from Parents Carrying Autosomal Recessive Alleles
Autosomal recessive inheritance is a type of genetic inheritance that occurs when two copies of a gene are needed for an individual to display a trait or disease. When two heterozygous carriers of a recessive allele have children, the percentage of unaffected children will depend on the specific gene in question. For example, according to a study conducted by Gudmundsson et al. (2020), heterozygous carriers of cystic fibrosis have a 25% chance of having an unaffected child, while those with polycystic kidney disease have a 75% chance. In other cases, studies show that the odds of having an unaffected offspring from two heterozygous carriers is much lower. For example, a 2016 study by Schrijver et al. found that when two carriers of homozygous hereditary spherocytosis have children, the odds of having an unaffected child is only 10%. Furthermore, parents heterozygous for alpha-thalassemia have a 0.5% chance of having an unaffected child, according to a study by Lahiri et al. (2021). Cont….
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