The Impact and Novelty of Protein Engineering: An Analysis of Schoof and Co-Workers’ Paper
Protein engineering has become a powerful tool for the development of novel therapeutic treatments and other beneficial products. Schoof and co-workers’ paper, published in 2016, has contributed significantly to the field by discussing various concepts and discoveries of protein engineering. Of the various concepts and discoveries presented in the paper, there are two that stand out as being particularly impactful and novel. The first concept that stands out as being impactful and novel is the development of a novel computational approach for engineering protein-protein interactions. Schoof and co-workers discuss the use of protein-protein interaction networks (PPINs) to promote the design of peptide sequences with desired properties (Schoof et al. 2016). This novel approach has been used to generate new peptide sequences that can be used to regulate protein-protein interactions in a variety of contexts, such as in drug discovery (Zhang et al., 2019). The second concept that is impactful and novel in the paper by Schoof and co-workers is the use of directed evolution to rationally engineer proteins with desired functions. This approach involves introducing random mutations into protein sequences and then selecting the desired variant (Schoof et al. 2016). Cont…
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