Sickle Cell Anaemia,In humans, the gene that produces the disease Sickle Cell Anaemia is ecessive to the gene for healthy haemoglobin production. a) How can two phenotypically healthy parents have a child who suffers from Sickle cell Anaemia? In your answer use suitable letters to show the genotypes of the parents, and include a Punnett diagram to show all the possibilities of the children’s genotypes. b) Based on the outcome of your Punnett diagram, state and explain the probability of a child being a sufferer of Sickle Cell Anaemia and the probability of a child not suffering from the disease. c) If an individual who suffers from Sickle cell disease has a child with someone who is healthy (and not carrying the sickle cell gene), what is the probability that the child would be a sufferer of Sickle Cell Anaemia?

Sickle Cell Anaemia

The gene that causes Sickle Cell Anaemia is recessive, meaning that it is only expressed when two copies of the gene are inherited (Kumar et al., 2019). For two phenotypically healthy parents to have a child suffering from Sickle Cell Anaemia, they must both carry one recessive gene, or homozygous recessive, for Sickle Cell Anaemia, denoted as ss (Bruno & Gordon, 2020). In order to illustrate the possibilities of the children’s genotypes, a Punnett diagram can be used. The Punnett diagram in Figure 1 below shows that if both parents are homozygous recessive for the gene for Sickle Cell Anaemia, there is a 25% chance that their child will be homozygous recessive for the gene, therefore will suffer from Sickle Cell Anaemia. Cont…

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