Metabolic Reactions of Drugs and Endogenous Substances,Give an example of a metabolic reaction of a drug or endogenous substance for each of the following reaction types and determine the electrophile and nucleophile (10 points): SN1 reaction Radical reaction E1 reaction The metabolic reaction needs to occur within the body – no in vitro tube reactions. Consider that most reactions occurring in the body will require an enzyme as a catalyst.

Metabolic Reactions of Drugs and Endogenous Substances

Metabolic reactions involving drugs and endogenous substances are complex biochemical processes that occur in the body. These reactions are mainly catalyzed by enzymes and involve the transformation of reactants into products. Most importantly, metabolic reactions are responsible for the elimination of drugs and endogenous substances from the body. Here, three common metabolic reaction types found in the body are discussed, including SN1, radical, and E1 reactions. The SN1 reaction involves a carbocation intermediate, which is the result of a proton transfer to the electrophile. As an example, the metabolic reaction of the endogenous substance cortisol occurs via an SN1-type reaction, with cytochrome P450 (CYP) enzymes as the catalysts (Chan et al., 2019). Here, the electrophile is a hydroxyl group and the nucleophile is a proton. Radical reactions involve the formation of a radical intermediate and are usually initiated by an external source of energy, such as ultraviolet light (Cline et al., 2016). For example, the drug ibuprofen is metabolized by the RXR-CYP enzyme complex via a radical reaction, with the electrophile being the… Cont…

Place your order
(550 words)

Approximate price: $22

Calculate the price of your order

550 words
We'll send you the first draft for approval by September 11, 2018 at 10:52 AM
Total price:
$26
The price is based on these factors:
Academic level
Number of pages
Urgency
Basic features
  • Free title page and bibliography
  • Unlimited revisions
  • Plagiarism-free guarantee
  • Money-back guarantee
  • 24/7 support
On-demand options
  • Writer’s samples
  • Part-by-part delivery
  • Overnight delivery
  • Copies of used sources
  • Expert Proofreading
Paper format
  • 275 words per page
  • 12 pt Arial/Times New Roman
  • Double line spacing
  • Any citation style (APA, MLA, Chicago/Turabian, Harvard)

Our guarantees

Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.

Money-back guarantee

You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.

Read more

Zero-plagiarism guarantee

Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.

Read more

Free-revision policy

Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.

Read more

Privacy policy

Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.

Read more

Fair-cooperation guarantee

By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.

Read more