Fatty Acid Degradation: A Three-Step Process Involving Seven Different Enzymes
Fatty acid degradation is a complex process that involves the sequential action of seven different enzymes. In the first step, fatty acids are converted to acetyl-CoA by a process known as ?-oxidation. This is followed by the formation of acyl-CoA, which can then be further degraded by a series of reactions known as the beta oxidation cycle (Liu et al., 2016). The final step involves the conversion of acyl-CoA to acetyl-CoA and then to carbon dioxide and water (Etherington et al., 2020). The pair that is mismatched is ?-oxidation and the beta oxidation cycle. While ?-oxidation is the first step in the fatty acid degradation process, the beta oxidation cycle occurs after the formation of acyl-CoA (Bursi et al., 2021). ?-oxidation is responsible for the conversion of fatty acids to acetyl-CoA, while the beta oxidation cycle further degrades the acyl-CoA to carbon dioxide and water. Therefore, ?-oxidation and the beta oxidation cycle are not the same process. Cont….
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