Exploring the Structural and Functional Significance of Aspartate Transcarbamoylase Bound to CTP
Aspartate transcarbamoylase (ATCase) is a key enzyme in the pyrimidine biosynthetic pathway, catalyzing the condensation of carbamoyl phosphate and aspartate (1). Aspartate transcarbamoylase bound to CTP (ATCase-CTP) plays a critical role in regulating the pyrimidine biosynthetic pathway, and has been studied extensively in recent years. Several structural and functional studies have been conducted to explore the structural and functional significance of ATCase-CTP. In 2016, a study was conducted to investigate the binding mechanism of ATCase-CTP using X-ray crystallography (2). The results of the study showed that the structure of ATCase-CTP was stabilized by hydrogen bonds and hydrophobic interactions. Additionally, the study showed that CTP-binding induced conformational changes in ATCase, which was critical for stabilizing the active site of the enzyme. More recently, a study was conducted in 2020 to investigate the structural and functional roles of ATCase-CTP in the catalytic cycle (3). The results of the study demonstrated that binding of CTP to ATCase increased the affinity of the enzyme for its substrates, leading to increased catalytic efficiency. Additionally, the study showed that CTP-binding induced conformational changes in ATCase, which were essential for stabilizing the active site and improving the efficiency of the catalytic cycle. Cont……
Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.
You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.Read more
Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.Read more
Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.Read more
Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.Read more
By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.Read more