Conversion of IMP to GMP: An Overview,Write the step(s) involved in converting IMP to GMP, including the structures of all reactants and products, and names of enzymes involved.

Conversion of IMP to GMP: An Overview

The conversion of inosine monophosphate (IMP) to guanosine monophosphate (GMP) is an important biochemical reaction in the formation of the purine nucleotides pool. The reaction involves the enzymatic activity of IMP dehydrogenase (IMPDH) and GMP synthetase (GMPS). The two enzymes catalyze two distinct steps in the conversion of IMP to GMP. The first step involves the removal of a hydrogen atom from the IMP structure to form xanthylate, which is catalyzed by IMPDH. The reaction is as follows: IMP + NAD+ -> xanthylate + NADH + H+ (Fung et al., 2016). The second step is the addition of an amino group to the xanthylate structure, which is catalyzed by GMPS. The reaction is as follows: xanthylate + ATP + glutamine -> GMP + ADP + Pi + glutamate (Kumar et al., 2017). The conversion of IMP to GMP is an important part of the purine nucleotide cycle, which is essential for the regulation of cellular metabolism and energy production. The two enzymes involved in the conversion of IMP to GMP are important regulators of this cycle and play an important role in maintaining the balance of purine nucleotides in the cell. Cont….

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