The Pathway of Gluconeogenesis: A Reverse of Glycolysis
Gluconeogenesis is the metabolic pathway that reverses the steps of glycolysis. It is the process of generating glucose from non-carbohydrate precursors, such as pyruvate, lactate and amino acids. In gluconeogenesis, the molecules of pyruvate and other molecules are converted into glucose, which is then used to fuel cellular activities. This process occurs in the liver, kidney and small intestine, and is essential for the maintenance of glucose homeostasis in the body (Liu et al., 2016). Gluconeogenesis is regulated by hormones, such as insulin and glucagon. During periods of low blood glucose, glucagon stimulates gluconeogenesis and glycogenolysis, while insulin inhibits the process (Cheung and Storlien, 2017). This ensures that glucose is available in the body when it is needed.
The pathway of gluconeogenesis is the reverse of glycolysis. This involves the conversion of pyruvate to glucose, the hydration of phosphoenolpyruvate to form fructose-1,6-bisphosphate, and the conversion of fructose-1,6-bisphosphate to glucose-6-phosphate, and other metabolic steps (Hou et al., 2021). Cont…
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