Which Statement about Sex Steroid Homeostasis is Incorrect?,Which statement about sex steroid homeostasis is incorrect: A. FSH induces estradiol production in granulosa cells in females B. LH induces spermatogenesis in Sertoli cells of males C. Aromatase converts testosterone to estradiol and aromatase inhibitors have been used to treat breast cancer. D. 5?-reductase converts testosterone to DHT, which is more a potent androgen than testosterone E. In females GnRH is secreted from pituitary to stimulate the secretion of LH and FSH in ovary

Which Statement about Sex Steroid Homeostasis is Incorrect?

The incorrect statement about sex steroid homeostasis is D. 5?-reductase converts testosterone to DHT, which is more potent androgen than testosterone. 5?-reductase actually converts testosterone to dihydrotestosterone (DHT), which is less potent than testosterone in terms of androgenic activity (Leung et al., 2018). This enzyme is mainly present in the scalp, prostate and male external genitalia (Urata et al., 2020). In contrast, A. FSH induces estradiol production in granulosa cells in females is correct. FSH does induce estradiol production in granulosa cells and is essential for the development of the follicle and the production of mature eggs (Ramirez et al., 2016).
Similarly, B. LH induces spermatogenesis in the Sertoli cells of males is correct. LH is needed for spermatogenesis, and its deficiency may lead to infertility in men (Botton et al., 2019).
C. Aromatase converts testosterone to estradiol and aromatase inhibitors have been used to treat breast cancer is also correctly. The aromatase enzyme is responsible for converting testosterone to estradiol, and this has been used as a strategy for the treatment of breast cancer (Pauwels et al., 2021). Cont…