Which type of enzyme is likely responsible for a tRNA being charged with an incorrect amino acid? O tRNA nucleotidel-transferase O translocase O aminoacyl-tRNA synthetase O peptidyltransferase O transformylase. The Role of Misfolded tRNA in Incorrect Amino Acid Charging

Misfolded TRNA and Incorrect Amino acid Charging

The role of tRNA in protein synthesis is crucial as it converts the genetic code to a sequence of amino acids. Studies have demonstrated that incorrectly folded tRNA may lead to improper amino acid charging. This can cause serious problems for cell function. Aminoacyl-tRNA synetases are the enzymes that charge the tRNA molecules with the right amino acid. This enzyme is highly specific, binding only one amino acid per tRNA. If the tRNA is not folded correctly, it can reduce its specificity, leading to inaccurate amino acid charges. Zeng and colleagues. Zeng et al. (2020) discovered that misfolded transcripts could cause the incorrect amino acids to be charged in the presence an aaRS enzyme. Further research by Xia et. al. (2016) further demonstrated that the misfolded structure of tRNA molecules can be altered to attach to multiple aaRS proteins, leading in multiple incorrectly charged amino acids. The incorrect charging of amino acids is most likely due to misfolded TRNA. The presence of an AaRS enzyme can cause misfolded transcript to adopt alternate structures, binding multiple AaRS enzymes. This results in multiple incorrect or multiple amino acid charges. Cont…..

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