What is the stoichiometry of GTP, ATP, and pyruvate in the production of glucose? Online it says 2 pyruvate, 4 ATP, and 2 GTP, but a tutor says 2 ATP and 1 GTP only. Am confused on which one it is! The Stoichiometry of GTP, ATP and Pyruvate in Glucose Production

Stoichiometry between GTP and ATP in Glucose production

The process of pyruvate or other molecules being converted to glucose, also known as gluconeogenesis is called glucose production. GTP, ATP and pyruvate are used in this process. The exact stoichiometry for each of these molecules is dependent on their species and conditions. GTP and ATP are generally 1:1 in the production of glucose, while pyruvate or glucose are 1:2. In the gluconeogenesis pathway, GTP and ATP are used to convert fructose-1,6-bisphosphate into fructose-6-phosphate, and then glucose-6-phosphate. This reaction requires a 1:1 ratio between GTP and ATP. The pyruvate-glucose reaction is also catalyzed using pyruvate carbonoxylase. This requires a 1:1 ratio of GTP and ATP (Heldt 2017; Aung and al. 2020). Cont….

Understanding the path of gluconeogenesis requires understanding the stoichiometry and ATP of GTP, ATP, pyruvate.