O’Methylguanine Mutation – Its Repair Mechanism
O’methylguanine is a type of DNA mutation that can result in a wide range of genetic disorders. O’ methylguanine is also called OMg. It is a method of base modification that substitutes the guanine-base of a nucleotide for a methylated guanine. One of the most frequent types of DNA damage is O’methylguanine mutation. It can result in genetic mutations which can be fatal. (Sander, 2018). O’ methylguanine is a type of DNA repair that must be used by cells to fix it. This system relies on enzymatic reactions in order to repair the proper base sequence. (Kumar et al.,2019). O’methylguanine (OMGT) is vital for the repair of O’ methylguanine DNA mutations and the prevention of the accumulation. This enzyme can detect incorrect bases and replace them with the right one. This is used to fix the mutation and bring back the proper base sequence. OMGT plays a role in preventing mistakes during DNA replication. (Zhang et al., 2021). Cont…
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